Author: Robin Cook
Newly divorced surgeon Dr. Kim Regis is determined to remain a good father to his only son, Selden. On a special night out, Kim takes Seldon to his favorite fast-food restaurant for a feast of burgers and fries. But the good time turns to tragedy: the young boy becomes gravely ill and dies as a result of poisoning by E. coli. bacteria found in the meat.Was Seldon's death a result of shoddy food-handling practices? Or was it a sophisticated case of product tampering - by a rival fast-foot giant or a disgruntled employee? Or perhaps by someone with a score to settle with Kim? Taking a leave from his surgical practice, Kim devotes his energies to solving the mystery full time. But he immediately hits a brick walls: a code of silence more impenetrable than anything he has ever encountered in his medical career. Instead of a cold-shoulder reception, however, Kim is soon met with a boot and a fist as thugs attempt to quash his inquiry.Aided by his ex-wife, Kim pursues a trail of deadly evidence, uncovering complicity and guilt stretching from the slaughterhouse floor to the corporate boardroom. Racing against time before more are poisoned, the two come face-to-face with the shocking and elusive truth. And in their life-and-death search for answers, they rediscover the reasons they first fell in love. With trademark pulse-pounding flair, Robin Cook delivers a cutting-edge thriller, borrowing from today's fears and tomorrow's medical technology.
Author: Alistair J. Lax
Publisher: OUP Oxford
What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants. In Toxin, Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defences of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and how apparently 'new' diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modern microbiology grew, Toxin is the first widely accessible account of this exciting and important topic.
The Toxin Solution
Author: Joseph Pizzorno
Eliminate avoidable toxins, mitigate the effects of those you can’t avoid, and enjoy a longer life with this essential health guide from a pioneer in integrative medicine, Dr. Joe Pizzorno—the author, teacher, practitioner, and founder of Bastyr University, the country’s first and largest fully accredited university of natural medicine. Dr. Joe Pizzorno is convinced that lifelong good health rests on two key determinants: your exposure to toxins and your ability to process them in your body. While lifestyle, diet, and genetics all play a major role in well-being, many symptoms of declining health and chronic disease are rooted in toxic overload—our exposure to a barrage of chemicals, heavy metals, radiation, electromagnetic frequencies, and pollution that are the byproducts of modern life. While the human body has an innate capacity to detoxify, it cannot cope with the elevated levels of toxins we are exposed to today. Most alarmingly, this toxic overload has helped transform once rare diseases into epidemics affecting people of all ages. In The Toxin Solution, Dr. Pizzorno provides the proven detox and tailored methods he has developed to heal toxic overload and restore health in just eight weeks. With this essential guide you will learn how to: Avoid toxins in food and the products you use; Mend your gut and prepare for detox; Support your body in releasing the chemicals; Repair some of the damage toxins have caused. Fortunately, our bodies have a tremendous capacity for healing and recovery. With The Toxin Solution you will discover how releasing and avoiding toxins can help you to feel better today—and every day for the rest of your life.
This book is a reference book based on the contribution made by eminent scientists (toxicologists) from the leading laboratories of the world. This book includes discussions of toxins produced by microbes, particularly fungi and bacteria, their chemical characterization, mechanism of action at the cellular and molecular level and also exploitation of TOX genes for the management of insect pests, weeds and plant pathogens.
This volume outlines and examines current understanding of botulinum toxin and its various therapeutic applications. It presents therapeutic uses across a variety of medical subspecialties and patient populations. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. Coverage also examines questions of immunity and explores economic issues. Written by leaders in their fields respected for their progressive approach to treatment, the book encourages responsible research into new and novel uses of botulinum toxin.
The exceptionally successful history of botulinum toxin and its likely future has hardly an equivalent. Initially, it was used in strabismus, blepharospasm and hemifacial spasm, later also in focal dystonia and spasticity and it has been shown to effectively treat wrinkles, hyperhidrosis and a great number of ensuing indications. By treating symptoms or disorders associated with pain, its analgesic effect was first noticed. The efficacy and reasons for this side effect have since been investigated and a number of models explaining the mode of action have been presented. However, even if we know that botulinum toxin undoubtedly helps in certain pain syndromes, there is still much work to do to identify the major ones, define the optimum dose and the preferred site of injection. Indicating current positions and kindling the growing interest in this extraordinary therapeutic agent this book presents a timely overview on pain management with botulinum toxin. Thus, it will be of great interest especially for anesthesiologists and neurologists in their clinical work and medical research.
This work represents a compilation of studies on the entry into and subsequent processing of several bacterial and plant toxins in mammalian cells. Emphasis is placed on the close parallel of mammalian cell processing of toxic proteins and physiologically essential ligands. This easy-to-read book includes chapters which review the structures of the toxins. It compares and contrasts the trafficking of pseudomonas and diphtheria toxins. It also discusses anthrax toxin and the clostridial neurotoxins.
Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.
This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.
The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.
This book surveys the use of botulinum toxin A in aesthetic medicine, including patient selection and evaluation, as well as rules and requirements. A section with tips and tricks makes this an invaluable resource for practicing dermatologists and plastic surgeons.
Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.
Algal and Fungal Toxins
Author: Solomon Kadis, Alex Ciegler, Samuel J. Ajl
Microbial Toxins, Volume VII: Algal and Fungal Toxins reviews research and investigations on algal and fungal toxins. This book discusses the distribution of poisonous dinoflagellates; pharmacology of blue-green algal toxins; control of Prymnesium and detection of toxin in nature; and F-2 (zearalenone) estrogenic mycotoxin from Fusarium. The effect of Fusarium toxins in animals; mycotoxins produced by Fusarium tricinctum NRRL 3249; and mold growth and production and isolation of trichothecenes are also elaborated. This publication likewise covers the chemistry of scirpene toxic substances of Fusarium nivale; isolation of salivation factor; and mammalian toxicity of epidithiadioxopiperazines. This volume is a useful reference for scientists and graduate students in various disciplines —microbiology, biochemistry, pharmacology, epidemiology, oncology, and related fields.
Botulinum Toxin E-Book
Author: Joseph Jankovic, Alberto Albanese, M. Zouhair Atassi, J. Oliver Dolly, Mark Hallett, Nathaniel H. Mayer
Publisher: Elsevier Health Sciences
The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.
Author: Ronald Sekura
Pertussis Toxin presents the proceeding of the Pertussis Toxin Conference, held in Bethesda, Maryland, on September 20–21, 1984. This book discusses the perspective of the pertussis toxin and the potential role of the toxin in the development of new acellular pertussis vaccines. Organized into 13 chapters, this text begins with an overview of the biological activities of pertussis vaccine, which enhanced the production of antibodies to antigens. This book then examines the interesting action of pertussis vaccine to stimulate antibody production, particularly as an effective adjuvant for the production of IgE isotype of antibodies. Other chapters consider the experimental approaches used in the study of the mechanisms by which hormones produce their physiological effect. The final chapter examines the several features of the Bordetella adenylate cyclase toxin, which suggest that the molecule may follow the A/B model proposed for a number of bacterial toxins. This book is a valuable resource for toxicologists, immunologists, bacteriologists, and pharmacologists.